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Find out what scientists have discovered could be an important cause for Type 2 Diabetes that could make us rethink the way we approach treatment for this devastating disease.

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Original Article: Pancreatic Beta Cell Dedifferentiation as a Mechanism of Diabetic Beta Cell Failure.
Talchai et al. Cell, 2012. 150 (6) p. 1223-1234.

Protein encourages beta-cell reproduction in the pancreas

A University of Oregon graduate student’s discovery could someday lead to new treatments for the nearly 1.5 million Americans with Type 1 diabetes. The research, led by Jennifer Hampton Hill in the UO lab of biologist Karen Guillemin, was detailed in a paper published in the journal eLife on Dec. 13, 2016.

A professor in the UO’s Department of Biology and the Institute of Molecular Biology who also serves as director of the META Center for Systems Biology, Guillemin examines the role bacteria play in animal development and disease. She uses a research model she helped develop involving a special kind of sterile zebrafish that don’t have any internal or external microbes of their own — no microbiome, making them germ-free — so scientists can better determine the role those microbes play as animals grow.

Having studied the pancreas and its importance to metabolism, and knowing that host metabolism can be strongly influenced by microbes, Hampton Hill naturally developed an interest in the role of bacteria in pancreatic development, which Guillemin encouraged.

Read more at https://around.uoregon.edu/BefA
Paper link: https://elifesciences.org/articles/20145
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